After some months of reseach in the web., i'm also starting to build a home B747-400 cockpit.
For the panel i decide to choose the FDS (Flight Deck Solutions Panel) from Peter Cos. I didn't regret it, first for the very competitive price and secondly for the quality of the panel they offer, they are laser cut with backlit capability.
For the hardware i have bought the USB EPIC card from R&R , i'll use a KE-24 keyboard encoder from hagstromelectronics for the FMS and for the software it'll be the fabulous Project Magenta glass cockpit of course.